Van de Ven Double Ends The Toffees' Run at Brand New Home Ground
Micky van de Ven emerged as the initial defender to net two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads home two times in opening period
Everton's defender has goal ruled after VAR review
Pape Matar Sarr scores final goal in dying moments
This loss is Everton's initial at their new ground
Micky van de Ven found the net twice as Tottenham prolonged their winning streak on the road in the Premier League and delivered Everton their first defeat at their new home.
Everton were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having left their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven struck twice from corners in the first half to put their strong form at risk, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward Richarlison - headed home a third to seal the victory.
Jake O'Brien believed he had equalized the tally five minutes after the defender's first goal, glancing a powerful header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a handful of opportunities, while the Italian goalkeeper made a succession of excellent stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR intervened, instructing the match official to check the goal on the pitchside monitor and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win moves Thomas Frank's side up to third in the Premier League, five points off north London rivals and leaders Arsenal.
The Merseyside club stay in 14th position and are half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender fulfils duties at both ends of the field
After a uninspiring weekday performance in the Champions League against Monaco, where they mustered a only attempts on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was unable to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball toward the six-yard box for an free Van de Ven to score.
And the captain - stepping up as captain in Cristian Romero's unavailability - added his next goal in added time as he outjumped Jordan Pickford to head home.
The Dutchman was equally outstanding in defence, combining effectively with Kevin Danso as the duo handled superbly with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing finishing touch
Everton's new home had been a fortress, but it appears the novelty may have worn off slightly and fans flocked to the gates after the midfielder's final goal for Spurs.
The end in the team's unbeaten home run won't be a massive concern for David Moyes, but their striker situation are.
Beto and the other striker - the Toffees' pair of established strikers - had netted just one league goal combined before the weekend's outing.
And they were unable to contribute to that poor tally on a damp and dreary evening on in Liverpool.
Beto's performance was summed up when he opted to overhead kick a clear chance from near the goal, despite having space and opportunity to reposition for a simpler shot that would have tested the keeper.
The substitute, as well, failed to make an impact after coming on for Beto in the 65th minute.
It was not for a shortage of opportunity. Most of Everton's attacks came through Grealish and the forward, who tirelessly delivered threatening balls into the Spurs box.
What next for both teams?
The Toffees: The team travel to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on late October for their next round League Cup match against Newcastle.